It happened Saturday morning on Interstate 49 about 2 miles north of Fouke, AR.
According to Miller County dispatch, there were 4 people involved in the crash. Two people were pronounced dead at the scene and the other 2 were flown to the hospital by LifeAir.
No names have been released at this time.
It is unclear how many vehicles were involved in the crash.
Arkansas State Police are investigating the crash.
Traffic in the area was shut down for a brief time and was reopened around 10:30 a.m.
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